Gabriela El Haje Lobo
Núcleos Centro de Medicina Nuclear, Brazil
Title: Experience and results of 42 patients after 177Lu-octreotate therapy in the Federal Capital of Brazil
Biography
Biography: Gabriela El Haje Lobo
Abstract
Introduction: Neuroendocrine tumors (NET) generally express somatostatin receptors (SR), allowing its treatment by radiolabeled somatostatin analogues (SA). Other tumors expressing these receptors are also amenable to such therapy.
Purpose: This paper aims to present the experience and the treatment results of 42 patients with 177Lu-octreotate in the Federal Capital of Brazil.
Subjects & Methods: 42 patients with progressing neuroendocrine and no neuroendocrine tumors with SR expression started the Rotterdam protocol with 177Lu-octreotate, from January 2008 to June 2016. These patients were selected after staging by anatomic imaging methods and SA affinity confirmed by scintigraphy, observing proper inclusion and exclusion criteria. Adverse effects during and after the doses administration were analyzed. 33 patients completed at least one cycle of treatment (4 doses of 200 mCi) and were assessed for clinical, laboratorial and anatomic response (complete, partial, stable or progression).
Conclusion: This ongoing experience of therapy with 177Lu-octreotate reproduced the literature data for safety and also for low incidence of side effects. Not only patients with NET, but also those with other tumors expressing affinity for the somatostatin analogs were benefited from this therapy.